Increased transendothelial migration of scleroderma lymphocytes

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Increased transendothelial migration of scleroderma lymphocytes.

BACKGROUND CD4+ T lymphocytes play an important part in the pathogenesis of scleroderma (systemic sclerosis, SSc) and predominate in perivascular SSc skin lesions. Both soluble and membrane bound adhesion molecules are overexpressed in SSc, possibly influencing lymphocyte/endothelial cell (EC) contact. OBJECTIVE To assess the transendothelial migration capacity of peripheral lymphocytes in vi...

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During allergic reactions, basophils migrate from the blood compartment to inflammatory sites, where they act as effector cells in concert with eosinophils. Because transendothelial migration (TEM) represents an essential step for extravasation of cells, for the first time we have studied basophil TEM using HUVEC. Treatment of HUVEC with IL-1beta significantly enhanced basophil TEM, which was f...

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Signaling in leukocyte transendothelial migration.

Under a variety of (patho) physiological conditions, leukocytes will leave the bloodstream by crossing the endothelial monolayer that lines the vessels and migrate into the underlying tissues. It is now clear that the process of extravasation involves a range of adhesion molecules on both leukocytes and endothelial cells, as well as extensive intracellular signaling that drives adhesion and che...

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Transendothelial migration of lymphocytes across high endothelial venules into lymph nodes is affected by metalloproteinases.

The migration of lymphocytes from the bloodstream into lymph nodes (LNs) via high endothelial venules (HEVs) is a prerequisite for the detection of processed antigen on mature dendritic cells and the initiation of immune responses. The capture and arrest of lymphocytes from flowing blood is mediated by the multistep adhesion cascade, but the mechanisms that lymphocytes use to penetrate the endo...

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ژورنال

عنوان ژورنال: Annals of the Rheumatic Diseases

سال: 2004

ISSN: 0003-4967

DOI: 10.1136/ard.2002.004838